We’re a specialist PK/PD modeling and biostatistics company

At Applied Pharma Modeling & Statistics Ltd. (ApPharMS), we provide Pharmacometrics (PK/PD, PBPK modeling, and MIDD) and Biostatistics services to generate timely decision-making results that have an impact on drug development programs.

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What We Do

Our aim is very simple: to deliver a mathematical model or statistical analysis that is customized to your decision-making needs and suited to your pre-clinical and/or clinical data. We can also help you in the early stages of the process by providing assistance with your study design (sample size calculations, time point selection for relevant biomarkers, input on dose level/frequency, etc.). This is to ensure that the data is fit for purpose and in line with the regulatory requirements.

Modeling & Simulation

Consultancy, design and implementation of PK/PD-model-informed drug development strategies (MIDD)

Mechanistic and data-driven PK/PD modeling

Pharmacologically-based PK modeling (PBPK)


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Biostatistics


Statistical support at the preclinical, translational, and early clinical stages, including study design

Other (custom-made/bespoke) modeling and statistics services



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Client Testimonials

“As consultant CMO for a well-funded biotech I worked with Cristian as the team pharmacometrician to help with understanding the pharmacology of a novel bispecific antibody and to develop a PK/PD model and sampling plan for a FiH study. Cristian worked responsively with the team delivering multiple analysis in a timely, flexible and dedicated manner to help with critical data to transition the molecule into clinic.”

Ajay Duggal, Founder & Managing Director

Adnovate Clinical

“Cristian did an exceptional job supporting our pre-clinical preparations through highly complex PK modeling. He handled a very complicated drug profile with precision and clarity, delivering insights that were both rigorous and actionable. His expertise, professionalism, and dedication made a significant impact on our project, and I would highly recommend him for any advanced pharmacokinetic modeling work.”

Ari Forman, CEO

Scatr Inc.

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The Technical Stuff

Dr. Cristian Gradinaru has an extensive background in the natural sciences (chemistry, biochemistry), pharmaceutical biostatistics and mathematical modelling: 

  • Therapeutic modalities: small molecules, biologics (antibodies, gene therapy, ADCs, etc.)  
  • Routes of administration: IV, IP, IT, inhaled, oral, etc.  
  • Disease areas: Oncology, Respiratory, Cardiovascular, Renal, etc. 
  • Statistics and PKPD modelling in the pharmaceutical industry
  • Biopharmaceutical implementations and practices.